000			02159cam a2200289 4500500
005			20250121155352.0
041			_afre
042			_adc
100	1	0	_aBrocario, Alexia _eauthor
700	1	0	_a Maurel, Stephan _eauthor
700	1	0	_a Kapoor, Katharina _eauthor
700	1	0	_a Lauze, Christophe _eauthor
700	1	0	_a Favrel, Stephanie _eauthor
245	0	0	_aAssessment of wound healing efficacy and tolerability using CicatrylTM cream based on a suction blister model in healthy subjects
260			_c2022.
500			_a70
520			_aBackgroundCicatrylTM cream, a topical medical device, is indicated for the treatment of superficial wounds and small skin injuries.ObjectivesTo assess the efficacy and tolerability of CicatrylTM cream by measuring the recovery of the skin barrier after inducing wounds.Materials & MethodsA suction blister of about 6-mm diameter was induced on the inner side of each forearm of 44 healthy subjects. Using a process of randomisation, CicatrylTM cream was then applied to one wound for a maximum duration of 14 days, while the other wound was left untreated. The primary objective was to evaluate the effect of the test product on wound healing at Day 6, by comparing treated versus untreated wound areas measured by macrophotography. Secondary objectives were to evaluate healing, cutaneous barrier restoration and subjective efficacy of the cream as well as tolerability.ResultsThe mean wound area (± SD) at Day 6 was significantly smaller for treated wounds compared with untreated wounds (1.76±4.71 vs 15.76±7.61 mm2; p 2/day; p ConclusionCicatrylTM cream improves wound healing, especially within the first six days, if applied in accordance with the manufacturer’s instructions.
690			_asuction blister model
690			_aTM
690			_aCicatryl
690			_acutaneous barrier restoration
690			_ahealing
690			_amacrophotography
690			_awound
786	0		_nEuropean Journal of Dermatology | 32 | 6 | 2022-11-01 | p. 762-769 | 1167-1122
856	4	1	_uhttps://shs.cairn.info/revue-european-journal-of-dermatology-2022-6-page-762?lang=en&redirect-ssocas=7080
999			_c604583 _d604583