000			02124cam a2200253 4500500
005			20250121155352.0
041			_afre
042			_adc
100	1	0	_aZhou, Xin _eauthor
700	1	0	_a Su, Jing _eauthor
700	1	0	_a Zhang, Chun-Lei _eauthor
700	1	0	_a Dai, Hui _eauthor
700	1	0	_a Wang, Wen-Hui _eauthor
245	0	0	_aDecreased expression of galectin-3 in the epidermis of psoriasis patients
260			_c2024.
500			_a1
520			_aBackgroundConventional histopathological features of psoriasis and atopic dermatitis often overlap.ObjectivesWe aimed to investigate Galectin-3 (Gal-3) expression in psoriatic skin lesions and its potential as an immunohistochemical marker for distinguishing between psoriasis and atopic dermatitis on a pathological basis.Materials & MethodsBased on immunohistochemical analysis, we assessed Gal-3 expression in formalin-fixed, paraffin-embedded tissue sections from 21 patients with psoriasis and 15 patients with atopic dermatitis. Quantitative analysis of expression intensity was performed using the average density (average optical density) method. We analysed the relationship between Gal-3 expression and clinical characteristics, as well as conventional histopathological features.ResultsPatients with psoriasis exhibited significantly decreased Gal-3 expression in the epidermis (0.11±0.05) compared to the atopic dermatitis group (0.36±0.15) and healthy controls (0.49±0.13) (pppppConclusionPatients with psoriasis show specific downregulation of epidermal Gal-3, correlating with epidermal thickness and neutrophil-related factors. Gal-3 may serve as an auxiliary discriminative marker between psoriasis and atopic dermatitis, potentially associated with keratinocyte proliferation and neutrophil function.
690			_aatopic dermatitis
690			_aimmunohistochemistry
690			_apsoriasis
690			_agalectin-3
786	0		_nEuropean Journal of Dermatology | 34 | 4 | 2024-07-09 | p. 371-377 | 1167-1122
856	4	1	_uhttps://shs.cairn.info/revue-european-journal-of-dermatology-2024-4-page-371?lang=en&redirect-ssocas=7080
999			_c604589 _d604589