000			02162cam a2200229 4500500
005			20250121155504.0
041			_afre
042			_adc
100	1	0	_aGambichler, Thilo _eauthor
700	1	0	_a Beilenhoff, Meike _eauthor
700	1	0	_a Rached, Nessr Abu _eauthor
700	1	0	_a Susok, Laura _eauthor
245	0	0	_aPrognostic clinical characteristics and systemic immune inflammatory biomarkers in 520 inpatients with herpes zoster: a retrospective analysis based on tertiary care hospitals
260			_c2024.
500			_a85
520			_aBackgroundHerpes zoster (HZ) is a very common disease associated with a considerable individual and public health burden.ObjectivesTo evaluate prognostic clinical and laboratory parameters, including systemic immune inflammatory biomarkers (SIIB) in inpatients with HZ.Materials & MethodsWe investigated clinical and laboratory data of 520 inpatients with HZ. Complete blood count was determined at baseline. SIIB was assessed based on neutrophil-to-lymphocyte ratio (NLR), pan-immune-inflammation value (PIV), and absolute eosinopenia (AEP). Both uni- and multivariable statistics were performed.ResultsNRL and PIV were significantly (p vs. healthy controls and. The presence of absolute eosinopenia (OR: 3.9, 95 % CI: 1.9 to 8.3) was a strong predictor of herpes zoster ophthalmicus (HZO). Ramsay-Hunt syndrome (OR: 4.3, 95 % CI: 1.8 to 10.3), bacterial superinfection (OR: 2.3, 95 % CI: 1.3 to 4.1), and age ConclusionWe identified several clinical and laboratory-based independent predictors that may aid prognostication of HZ patients. The increase in SIIB reflects the possible role of systemic inflammatory alterations in HZ. However, the only effective SIIB studied was AEP which was independently associated with HZO. The use of intravenous antiviral therapy decreases the risk of postherpetic neuralgia.
690			_abiomarkers
690			_aprognosis
690			_aherpes zoster
786	0		_nEuropean Journal of Dermatology | 34 | 5 | 2024-11-09 | p. 502-508 | 1167-1122
856	4	1	_uhttps://shs.cairn.info/revue-european-journal-of-dermatology-2024-5-page-502?lang=en&redirect-ssocas=7080
999			_c604910 _d604910