| 000 | 02359cam a2200301 4500500 | ||
|---|---|---|---|
| 005 | 20250123095918.0 | ||
| 041 | _afre | ||
| 042 | _adc | ||
| 100 | 1 | 0 |
_aSahin, Kazim _eauthor |
| 700 | 1 | 0 |
_a Orhan, Cemal _eauthor |
| 700 | 1 | 0 |
_a Kucuk, Osman _eauthor |
| 700 | 1 | 0 |
_a Erten, Fusun _eauthor |
| 700 | 1 | 0 |
_a Tuzcu, Mehmet _eauthor |
| 700 | 1 | 0 |
_a Sahin, Nurhan _eauthor |
| 700 | 1 | 0 |
_a Perez Ojalvo, Sara _eauthor |
| 700 | 1 | 0 |
_a Komorowski, James Richard _eauthor |
| 245 | 0 | 0 | _aEffects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats |
| 260 | _c2021. | ||
| 500 | _a58 | ||
| 520 | _aThe objective of this study was to investigate the effects of a novel form of biotin (magnesium biotinate) on serum glucose, lipid profile, and hepatic lipid metabolism-related protein levels in rats. Forty-two rats were divided into six groups and fed a standard diet-based egg white powdered diet supplemented with either d-biotin at 0.01, 1, or 100 mg/kg BW or magnesium biotinate at 0.01, 1, or 100 mg/kg BW for 35 days. Neither form of biotin influenced (p > 0.05) serum glucose or insulin concentrations. Serum total cholesterol and triglyceride decreased with biotin from both sources (p < 0.05). Concentrations were lower with magnesium biotinate when comparing the 1 mg/kg dose (p < 0.05). Serum, liver, and brain biotin and liver cyclic guanosine monophosphate (cGMP) concentrations were greater when rats were treated with magnesium biotinate versus d-biotin, particularly when comparing the 1 and 100 mg/kg dose groups (p < 0.05). Both biotin forms decreased the liver SREBP-1c and FAS and increased AMPK-α1, ACC-1, ACC-2, PCC, and MCC levels (p < 0.05). The magnitudes of responses were more emphasized with magnesium biotinate. Magnesium biotinate, compared with a commercial d-biotin, is more effective in reducing serum lipid concentrations and regulating protein levels of lipid metabolism-related biomarkers. | ||
| 690 | _amagnesium biotinate | ||
| 690 | _aglucose | ||
| 690 | _aD-biotin | ||
| 690 | _ainsulin | ||
| 690 | _alipid parameters | ||
| 786 | 0 | _nMagnesium Research | 34 | 1 | 2021-01-01 | p. 9-19 | 0953-1424 | |
| 856 | 4 | 1 | _uhttps://shs.cairn.info/revue-magnesium-research-2021-1-page-9?lang=en&redirect-ssocas=7080 |
| 999 |
_c755395 _d755395 |
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