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Introduction: Skin disorders in psychiatric patients are common and under-diagnosed. Their association is bidirectional—that is to say, each of these two conditions may have a potential effect on the emergence, development, aggravation, or persistence of the other. Objectives: The aim of our study was to determine the prevalence and profile of various skin diseases observed in psychiatric patients. Methods: We conducted a cross-sectional study over a twelve-month period from November 2011 to December 2012, in collaboration with the department of dermatology and the department of psychiatry of the University Hospital Center Hassan II in Fez, Morocco. It involved patients hospitalized or in consultation at a psychiatric hospital. Results: Over a period of 12 months, 300 patients were included in our study. We recorded 250 cases of skin diseases (83%). A total of 33% of patients were hospitalized and 67% were examined in consultation. The mean age of the patients was 27 years. The psychiatric disorders concerned were schizophrenia in 39% of cases and depression in 32% of cases. Dermatological diagnoses were divided into five categories: dermatoses associated with poor hygiene, largely infectious diseases (18%), dermatoses secondary to mental disorders (22.3%), dermatoses influenced by psychological disorders (24%), dermatoses responsible for psychiatric disorders (10%), and skin disorders iatrogenic to psychotropic treatment (1.3%). Discussion: Dermatoses associated with poor hygiene are observed with significant frequency within the group of schizophrenic hospitalized patients, which could be explained by these patients’ lack of concern for their cleanliness. Conclusion: The presence of an interaction between the skin and the brain and the resulting clinical implication justifies a close collaboration between psychiatrist and dermatologist to improve overall care for both types of pathologies.