Lifetime risk assessment of exposure to a mixture of trace elements
Gastellu, Thomas
Lifetime risk assessment of exposure to a mixture of trace elements - 2025.
53
Exposure to chemical substances can trigger health adverse effects throughout life. Health agencies assess the risks associated with this exposure for the general population or part of it. Health risk assessments are generally carried out for a single substance, a single route of exposure, and by age group. Our study developed a method for estimating lifetime exposure (dietary and environmental) to a mixture of trace elements. This approach is based on estimating the external lifetime exposure of a fictitious population representative of the French population, taking into account the socio-economic and socio-demographic determinants of exposure. Physiologically-based kinetic models were used to estimate internal exposure throughout life. On the medians, our estimates are consistent with the results from biomonitoring studies of the French population. On the basis of a common effect (i.e. nephrotoxicity), it was therefore possible to characterise the risk associated with exposure to four trace elements throughout life. Our conclusions are that there is a risk that cannot be ruled out throughout life for the mixture of the four trace elements. Estimating internal exposure during specific periods of life, e.g. pregnancy or the post-natal period, are the next objectives of this work.
Lifetime risk assessment of exposure to a mixture of trace elements - 2025.
53
Exposure to chemical substances can trigger health adverse effects throughout life. Health agencies assess the risks associated with this exposure for the general population or part of it. Health risk assessments are generally carried out for a single substance, a single route of exposure, and by age group. Our study developed a method for estimating lifetime exposure (dietary and environmental) to a mixture of trace elements. This approach is based on estimating the external lifetime exposure of a fictitious population representative of the French population, taking into account the socio-economic and socio-demographic determinants of exposure. Physiologically-based kinetic models were used to estimate internal exposure throughout life. On the medians, our estimates are consistent with the results from biomonitoring studies of the French population. On the basis of a common effect (i.e. nephrotoxicity), it was therefore possible to characterise the risk associated with exposure to four trace elements throughout life. Our conclusions are that there is a risk that cannot be ruled out throughout life for the mixture of the four trace elements. Estimating internal exposure during specific periods of life, e.g. pregnancy or the post-natal period, are the next objectives of this work.
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