Lifetime risk assessment of exposure to a mixture of trace elements (notice n° 1573008)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01918cam a2200181 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20251214025807.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Gastellu, Thomas |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Lifetime risk assessment of exposure to a mixture of trace elements |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2025.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 53 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Exposure to chemical substances can trigger health adverse effects throughout life. Health agencies assess the risks associated with this exposure for the general population or part of it. Health risk assessments are generally carried out for a single substance, a single route of exposure, and by age group. Our study developed a method for estimating lifetime exposure (dietary and environmental) to a mixture of trace elements. This approach is based on estimating the external lifetime exposure of a fictitious population representative of the French population, taking into account the socio-economic and socio-demographic determinants of exposure. Physiologically-based kinetic models were used to estimate internal exposure throughout life. On the medians, our estimates are consistent with the results from biomonitoring studies of the French population. On the basis of a common effect (i.e. nephrotoxicity), it was therefore possible to characterise the risk associated with exposure to four trace elements throughout life. Our conclusions are that there is a risk that cannot be ruled out throughout life for the mixture of the four trace elements. Estimating internal exposure during specific periods of life, e.g. pregnancy or the post-natal period, are the next objectives of this work. |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Le Bizec, Bruno |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rivière, Gilles |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Environnement, Risques & Santé | 24 | 5 | 2025-10-07 | p. 287-298 | 1635-0421 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://stm.cairn.info/journal-environnement-risques-sante-2025-5-page-287?lang=en&redirect-ssocas=7080">https://stm.cairn.info/journal-environnement-risques-sante-2025-5-page-287?lang=en&redirect-ssocas=7080</a> |
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