Angiopathie amyloïde cérébrale de forme sporadique (notice n° 259609)
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| fixed length control field | 03897cam a2200325 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250112073755.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Puy, Laurent |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Angiopathie amyloïde cérébrale de forme sporadique |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2019.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 68 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | L’angiopathie amyloïde cérébrale (AAC) de forme sporadique est une vasculopathie cérébrale causée par des dépôts de peptides Aß -amyloïdes dans la paroi des vaisseaux corticaux et leptoméningés. Sa physiopathologie est complexe mais est dominée par un déséquilibre entre la production et l’élimination des peptides amyloïdes. Son incidence augmente avec le vieillissement de la population. L’AAC est une cause majeure d’hémorragie cérébrale lobaire spontanée du sujet âgé dont le pronostic est particulièrement sombre. L’atteinte cognitive et les épisodes déficitaires focaux transitoires (symptômes neurologiques stéréotypés et récidivants) en sont les autres manifestations cliniques. L’IRM cérébrale est l’examen d’imagerie de choix pour évoquer le diagnostic, permettant de visualiser l’hémorragie cérébrale lobaire mais également les autres marqueurs radiologiques d’AAC qui témoignent de la sévérité de la micro-angiopathie (microsaignements corticaux, sidérose corticale superficielle, hypersignaux de la substance blanche d’origine vasculaire, espaces dilatés périvasculaires et micro-infarctus). En pratique clinique, le diagnostic d’AAC repose sur un faisceau de données cliniques et radiologiques correspondant aux critères de Boston modifiés. Il n’existe aucun traitement spécifique de l’AAC actuellement. La prise en charge médicamenteuse repose essentiellement sur un contrôle tensionnel strict et une évaluation rigoureuse de la balance bénéfice-risque des antithrombotiques. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Sporadic cerebral amyloid angiopathy (CAA) is a small vessel disease caused by vascular deposits of Aß-amyloid peptides in the walls of cortical and leptomeningeal vessels. Advancing age is the strongest known clinical risk factor for developing CAA. This devastating disease occurs frequently in elderly people, and is a frequent cause of symptomatic lobar intracerebral hemorrhage (ICH), cognitive impairment and transient focal neurological episodes. Typical cerebral MRI findings include lobar intracerebral hemorrhages and neuroimaging biomarkers of CAA (lobar cerebral microbleeds, cortical superficial siderosis, white matter hyperintensities, dilated perivascular spaces and microinfarcts). In the absence of direct neuropathological examination, the most commonly used criteria for CAA diagnosis are the modified Boston criteria based on clinical and MRI data. To date, no specific treatment is available to prevent bleeding or cognitive decline. Thus, management is mainly based on strict blood pressure control. Anticoagulation should usually be avoided in patients with a diagnosis of CAA and symptomatic lobar ICH. The risk/benefit ratio evaluation at individual level of antiplatelet agents is also required. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | sidérose corticale superficielle |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | démence |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | hémorragie cérébrale lobaire |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | troubles cognitifs |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | angiopathie amyloïde cérébrale |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | microsaignements cérébraux |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | cerebral amyloid angiopathy |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | cognitive disorders |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | lobar intracerebral haemorrhage |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | cortical superficial siderosis |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | cerebral microbleeds |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | dementia |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cordonnier, Charlotte |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Gériatrie et Psychologie Neuropsychiatrie du Vieillissement | 17 | 1 | 2019-03-01 | p. 73-82 | 2115-8789 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-geriatrie-et-psychologie-neuropsychiatrie-du-vieillissement-2019-1-page-73?lang=fr">https://shs.cairn.info/revue-geriatrie-et-psychologie-neuropsychiatrie-du-vieillissement-2019-1-page-73?lang=fr</a> |
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